![]() ![]() Some routes are considered more beneficial, and others more harmful to health. To further complicate the picture, there are multiple possible routes through these steps too. Oestrogen production, processing, metabolism and elimination is complex and involves lots of different steps. And once used, they must then be metabolised before they can be eliminated in urine or faeces. Once produced, oestrogens need to be processed or ‘activated’ before they can exert their biological effects. Both males and females produce and need oestrogens, in differing amounts. The term ‘oestrogen’ is used to collectively describe a group of hormones (oestrone (E1), oestradiol (E2) & oestriol (E3)) which have widespread actions throughout the body. In a bid to increase confidence and understanding in this area, here’s a bit of background and a simple overview of each compound, including information on when you might consider recommending in a clinical setting.įirst a bit of background. Unfortunately, confusion reigns supreme over the mechanism of action and potential clinical application of each. Several compounds, including DIM, I3C, sulforaphane and calcium-d-glucarate have the potential to impact this in a beneficial way. The way the body handles oestrogens is an important factor affecting both male and female health. Find out more about our editorial process. J Steroid Biochem Mol Biol 2015 Sep 153:35-44.Why you can trust Nutri Advanced Every article on our site is researched thoroughly by our team of highly qualified nutritionists. Aromatase overexpression in dysfunctional adipose tissue links obesity to postmenopausal breast cancer. Journal of Ovarian Research volume 8, Article number: 11 (2015) The correlation of aromatase activity and obesity in women with or without polycystic ovary syndrome. Aromatase, breast cancer and obesity: a complex interaction. Cytostatic and antiestrogenic effects of 2-(indol-3-ylmethyl)-3,3′-diindolylmethane, a major in vivo product of dietary indole-3-carbinol. Modulation of CYP19 expression by cabbage juices and their active components: indole-3-carbinol and 3,3′-diindolylmethene in human breast epithelial cell lines. Journal of the National Cancer Institute. Indolo(3,2-b)carbazole: a dietary-derived factor that exhibits both antiestrogenic and estrogenic activity. Provita offers 2 highly efficient products containing Indole-3-Carbinol and DIM: In conclusion, Indole-3-carbinol is useful for both men and women. Recently, researchers have discovered that there is also a connection between aromatase and obesity,. In women, during pre-menopause and menopause but more recently even in young women, excess estrogen increases the risk of breast cancer. I3C might be able to counteract this by restricting estrogen. Older men's lower testosterone to estrogen ratio can result in health problems such as gynecomastia, loss of muscle tissue, fat accumulation, alopecia, enlarged prostate, loss of libido, and erectile dysfunction. This is beneficial for both women and men, and very important for older men with low testosterone levels due to ageing. Decreasing the presence of aromatase can limit the amount of testosterone that is replaced by estrogen. I3C and its constituent DIM, down-regulate the expression of aromatase, or CYP19, which is the protein responsible for converting testosterone into estrogen. Indole-3-carbinol is useful for both men and women Downregulation of aromatase in men The result of these pathways is the release of testosterone bound to sex-hormone binding globulin (SHBG), which enables testosterone to cross the blood-brain barrier and produce its effects throughout the body. Promotes metabolization of estrogen and increase the ratio of 2-hydroxyestrone (“good” estrogen metabolite) to 16alpha-hydroxy Estrone (“bad” estrogen metabolite),.The truth is that men may also have problems with excess estrogen and reduced levels of testosterone with negative impact on prostate and sexual health.Īlthough indole-3-carbinol does not directly elevate testosterone levels, studies have shown that I3C may indirectly influence testosterone via anti-estrogenic pathways : It was previously believed that only women can develop problems with estrogen levels. ![]() It's most prominent bio-activity is to alter the metabolism of estrogen, which in turn impacts testosterone levels. More recently, it was discovered that I3C modulates the expression and activity of enzymes involved in the regulation of hormones. Indole-3-Carbinol or in short I3C is a compound well known for a wide-range of health applications such as anti-inflammatory and anti-atherogenic, supporting antioxidant enzymes and boosting the immune system. ![]()
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